{"id":1690,"date":"2026-01-24T08:35:20","date_gmt":"2026-01-24T08:35:20","guid":{"rendered":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/neuroendocrine-tumor-of-the-mediastinum-of-unknown-primary-origin-in-a-woman\/"},"modified":"2026-01-24T08:35:20","modified_gmt":"2026-01-24T08:35:20","slug":"neuroendocrine-tumor-of-the-mediastinum-of-unknown-primary-origin-in-a-woman","status":"publish","type":"post","link":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/neuroendocrine-tumor-of-the-mediastinum-of-unknown-primary-origin-in-a-woman\/","title":{"rendered":"NEUROENDOCRINE TUMOR OF THE MEDIASTINUM OF UNKNOWN PRIMARY ORIGIN IN A WOMAN"},"content":{"rendered":"
Tsoukalas N., Lypas G., Papakostidi A., Droufakou S., Barbounis V., Efremidis A. <\/div>\n
2nd Opt Clinical Oncology, "Saint Sawas" Anticancer Hospital, Athens, Greece.<\/div>\n
\n

Aim: <\/strong>The description and analysis of an interesting case of neuroendocrine tumor of the mediastinum in a young female. <\/p>\n

Case report: <\/strong>Female, 42 years old, smoker (10 pys), with no previous medical history but positive family history (the mother's brother suffered from lung cancer), in the beginning of 2007 presented with fatigue, weakness, dry cough and pain in the right shoulder and right cervical area. A CT of the thorax was performed which showed a mass in the upper mediastinum (33x33mm), a block of lymph nodes in the right paratracheal area and a nodule (4,5mm) in the right upper lobe of the lung. The patient underwent a mediastinoscopy and surgical excision of the mass from the mediastinum, the paratracheallymphnodes and the nodule from the lung. The histological examination revealed a large cell neuroendocrine neoplasm (5,8cm) of low differentiation with infiltration of lymph nodes of the mediastinum (large cell neuroendocrine carcinoma, poorly differentiated, WHO 2004). The immunohistochemical examination revealed positivity for CD56, Synaptophysin, AE3, CK7, CDl17, NSE, and Ki67 >50%. NSE was 50ng\/ml and Chromogranin 44ng\/ml. The rest of the workup with CTs ofthe brain and abdomen and bone scan was negative for metastases. Staging of the disease: T2N3MO, stage IIiB. A diagnostic octreoscan was performed which showed positivity in the right hilar of the lung. The patient received 6 cycles of chemotherapy with Docitaxel75mg\/m2 and Cisplatin 75mg\/m2, q3w and then radiotherapy of the mediastinum. Seven months after the completion of radiotherapy and due to intense lower back pain, she underwent diskectomy of the 5th lumbar and the 1 st sacral vertebra (L5-S1). Three months later she presented with intense abdominal pain. The CT of the abdomen showed a mass between the head and body of the pancreas (5x4cm) and enlargement of the left ovary. The MRI of the abdomen showed 3 masses in the minor omental bursa, in front and above the pancreas, with a major dimension of Scm, and 2 cysts (2,3 and 4,5cm) in the left ovary. A FNA of the pancreatic mass was done and the diagnosis was neuroendocrine neoplasm, positive for CD56, NSE and Synaptophysin. From the rest of the workup: NSE=142,9ng\/ml «16,3), antiTG=657,9IU\/ml «70), Chromogranin=607ng\/ml (19,498,1), S-100=0,379µm\/1 «0,105) and Gastrin 573ng\/ml «180). Insulin, C -peptide, Calcitonin, PTH, ACTH and VMA of the urine were all in normal range. The upper GI endoscopy was normal. During her hospitalization the patient developed headache and scotomas. An MRI of the brain revealed a single metastatic lesion (27mm) in the left hemisphere of the cerebellum, with surrounding oedema She was then administered radiotherapy followed by chemotherapy with carboplatin and etoposide. <\/p>\n

Conclusion:<\/strong> The primary neuroendocrine neoplasms of the mediastinum are rare. They can be well to poorly differentiated. The histogenesis of these tumors varies and they can come from ectopic tissue in the mediastinum or they can be directly related to the thymus. The histological features and the usual immunohistochemical markers can't fine the origin of the neuroendocrine tumors. That makes it difficult to establish the primary origin of a metastatic neuroendocrine tumor. <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Tsoukalas N., Lypas G., Papakostidi A., Droufakou S., Barbounis V., Efremidis A. 2nd Opt Clinical Oncology, "Saint Sawas" Anticancer Hospital, Athens, Greece. Aim: The description and analysis of an interesting case of neuroendocrine tumor of the mediastinum in a young female. Case report: Female, 42 years old, smoker (10 pys), with no previous medical history Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52,2,11],"tags":[],"class_list":["post-1690","post","type-post","status-publish","format-standard","hentry","category-volume-9-issue-2","category-journal-articles","category-volume-9"],"_links":{"self":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1690","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/comments?post=1690"}],"version-history":[{"count":0,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1690\/revisions"}],"wp:attachment":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/media?parent=1690"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/categories?post=1690"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/tags?post=1690"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}