{"id":1608,"date":"2026-01-24T08:35:20","date_gmt":"2026-01-24T08:35:20","guid":{"rendered":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/7b2-plasma-levels-in-patients-with-congestive-cardiac-failure\/"},"modified":"2026-01-24T08:35:20","modified_gmt":"2026-01-24T08:35:20","slug":"7b2-plasma-levels-in-patients-with-congestive-cardiac-failure","status":"publish","type":"post","link":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/7b2-plasma-levels-in-patients-with-congestive-cardiac-failure\/","title":{"rendered":"7B2 PLASMA LEVELS IN PATIENTS WITH CONGESTIVE CARDIAC FAILURE"},"content":{"rendered":"
Venetikou S.M.1<\/sup>, Meleagros L.2<\/sup>, Ghatei M.3<\/sup>, Bloom R.S.3<\/sup><\/div>\n
1<\/sup> Department of Essential Medical Lessons, Faculty of Health and Caring Professions, Technological Educational lnstitution (TEl), Athens, Greece, 2<\/sup>Department of Surgery, North Middlesex University Hospital, Edmonton, London, UK, 3<\/sup>Departmentoflnvestigative Medicine, Imperial College, Hammersmith Hospital, London, UK <\/div>\n
Background:<\/strong> 7B2 is a pituitary protein, found to be increased in patients with a variety of endocrine tumours; it has been considered to be a neuroendocrine tumour marker. <\/p>\n

Aim:<\/strong> A study was undertaken to estimate 7B2 immunoreactivity (7B2 – IR) in patients with congestive heart failure (CCF). <\/p>\n

Methods:<\/strong> A total of 31 patients (26 male,S female) with stable chronic CCF were included in the study. The patients were aged 23 – 77 (53.3±12.4 [SO]) years. The causes of CCF were ischaemic (n=19) or dilated (n=12) cardiomyopathy. Patients were classified according to the New York Heart Association (NYHA) classification on the basis of shortness of breath (NYHA I (n=5), NYHA II (n=l 0), NYHA III (n=ll), NYHA IV (n=5). All patients had systolic and diastolic blood pressure estimations and jugular vein pressure (NP) estimations (n=17) with reference to the sternal angle. Left ventricular ejection fraction % (LVEF %) was measured (n=24) using a radionucleotide ventriculographyy. Electrolytes, urea, creatinine and osmolality (n=17) were estimated. Plasma 7B2 -IR (n=31) was also estimated with a sensitive RIA. Plasma 7B2 – IR was measured in 8 (5 male, 3 female) age matched (48 – 57 [57.5±6.5) years subjects without CCF. Statistical significances were calculated using two tailed t – tests. <\/p>\n

Results:<\/strong> Comparisons of the haemodynamic plasma variables in mild (NYHA 1+11) and severe (NYHA 1I1+IV) CCF showed no significant differences in LVEF%, diastolic blood pressure, or jugular venous pressure. However, systolic blood pressure was significantly lower and plasma creatinine significantly higher in severe CCF. In 8 healthy volunteers who had complained of chest pain, but showed no evidence of coronary pathology on angiography, 7B2 -IR was 30.2±1.4 pmol\/l. Plasma 7B2 – IR in all patients with CCF was 49.5±3.8 pmol\/I (n=31) (p<0.05) compared to controls.A representative plasma 7B2 chromatographic profile obtained from patients with CCF, showed that 7B2 eluted at the expected position. <\/p>\n

Summary\/Conclusions:<\/strong> The paneuroendocrine tumour marker 7B2 was found to be significantly increased in patients with CCF. <\/div>\n","protected":false},"excerpt":{"rendered":"

Venetikou S.M.1, Meleagros L.2, Ghatei M.3, Bloom R.S.3 1 Department of Essential Medical Lessons, Faculty of Health and Caring Professions, Technological Educational lnstitution (TEl), Athens, Greece, 2Department of Surgery, North Middlesex University Hospital, Edmonton, London, UK, 3Departmentoflnvestigative Medicine, Imperial College, Hammersmith Hospital, London, UK Background: 7B2 is a pituitary protein, found to be increased in Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52,2,11],"tags":[],"class_list":["post-1608","post","type-post","status-publish","format-standard","hentry","category-volume-9-issue-2","category-journal-articles","category-volume-9"],"_links":{"self":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/comments?post=1608"}],"version-history":[{"count":0,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1608\/revisions"}],"wp:attachment":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/media?parent=1608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/categories?post=1608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/tags?post=1608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}