{"id":1391,"date":"2026-01-24T08:35:20","date_gmt":"2026-01-24T08:35:20","guid":{"rendered":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/interaction-of-time-on-selenium-induced-reduction-of-anti-tpo-concentrations-in-patients-with-autoim\/"},"modified":"2026-07-29T18:40:37","modified_gmt":"2026-07-29T18:40:37","slug":"interaction-of-time-on-selenium-induced-reduction-of-anti-tpo-concentrations-in-patients-with-autoim","status":"publish","type":"post","link":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/interaction-of-time-on-selenium-induced-reduction-of-anti-tpo-concentrations-in-patients-with-autoim\/","title":{"rendered":"INTERACTION OF TIME ON SELENIUM INDUCED REDUCTION OF ANTI-TPO CONCENTRATIONS IN PATIENTS WITH AUTOIMMUNE THYROIDITIS"},"content":{"rendered":"
Duntas L.1<\/sup>, Boutsiadis A.1<\/sup>, Loukari E.1<\/sup>, Mantzou E.1<\/sup>, Pitsouni E.2<\/sup><\/div>\n
1<\/sup>Endocrine Unit, Evgenidion Hospital, University of Athens, Greece, 2<\/sup>Biomedical Laboratory, Evgenidion Hospital, University of Athens,Greece<\/div>\n
\n

Abstract<\/h2>\n

Objective and Aim:<\/strong> Selenium supplementation can decrease anti-TPO levels in patients with autoimmune thyroiditis (AIT. This study was performed to evaluate the relationship between serum selenium concentrations and the course of anti-TPO over time.
Methods:<\/strong> Seventy consecutive AIT patients were randomly grouped according to the degree of the disease based on ultrasound examination and anti-TPO determination: severe: anti-TPO >1000 U\/L, (Gr1, n=31) and moderate: anti-TPO < 1.000 U\/L (Gr2, n=39). All patients were treated with selenomethionine 200μg\/day and LT4 individually tailored to maintain TSH at around 1 mU\/L. Selenium, TSH and anti-TPO were determined at the baseline, at 4 and 24 weeks thereafter.
Results:<\/strong> Gr1 had significantly higher anti-TPO values (2335±1133,mean±sd) at baseline compared to Gr2 (485±247; p<0.001). A notable reduction of anti-TPO levels in both groups over time (Gr1: -39.86%; Gr2: -14.80%, p><0.001, from baseline to W24) was detected. Anti-TPO levels were differently reduced by 2.45% from baseline to W4 and by 38.35% from W4 to W24 in Gr1 and by 2.29% and 12.80% in Gr2, respectively. The interaction between time and basal selenium values and groups was statistically significant (p><0.01). Ignoring the time character of the data, it may be hypothesized that basal Se does not directly affect anti-TPO when using longitudinal models. Anti-TPO had a highly significant (p><0.001) negative relation with Se.
Conclusions:<\/strong> The results indicate that the reduction of anti-TPO by Se depends on baseline Se values and that the main effect of time (reduction of anti-TPO) depends on the severity of disease, since different reductions were achieved in group 1 and 2.The effect of Se in anti-TPO over time was negative (higher Se leads to lower anti-TPO), being statistical significant (p><0.001)for both groups. <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Duntas L.1, Boutsiadis A.1, Loukari E.1, Mantzou E.1, Pitsouni E.2 1Endocrine Unit, Evgenidion Hospital, University of Athens, Greece, 2Biomedical Laboratory, Evgenidion Hospital, University of Athens,Greece Abstract Objective and Aim: Selenium supplementation can decrease anti-TPO levels in patients with autoimmune thyroiditis (AIT. This study was performed to evaluate the relationship between serum selenium concentrations and the Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-1391","post","type-post","status-publish","format-standard","hentry","category-journal-articles"],"_links":{"self":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1391","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/comments?post=1391"}],"version-history":[{"count":1,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1391\/revisions"}],"predecessor-version":[{"id":11832,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1391\/revisions\/11832"}],"wp:attachment":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/media?parent=1391"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/categories?post=1391"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/tags?post=1391"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}