{"id":1355,"date":"2026-01-24T08:35:20","date_gmt":"2026-01-24T08:35:20","guid":{"rendered":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/the-beneficial-effect-of-l-thyroxine-on-cardiovascular-risk-factors-in-patients-with-subclinical-hyp\/"},"modified":"2026-01-24T08:35:20","modified_gmt":"2026-01-24T08:35:20","slug":"the-beneficial-effect-of-l-thyroxine-on-cardiovascular-risk-factors-in-patients-with-subclinical-hyp","status":"publish","type":"post","link":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/the-beneficial-effect-of-l-thyroxine-on-cardiovascular-risk-factors-in-patients-with-subclinical-hyp\/","title":{"rendered":"THE BENEFICIAL EFFECT OF L-THYROXINE ON CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM CAUSED BY AUTOIMMUNE THYROIDITIS"},"content":{"rendered":"
Neves C.1<\/sup>, Alves M.1<\/sup>, Pereira M.1<\/sup>, Ramalho R.2<\/sup>, Ramos J.P.2<\/sup>, Guimaraes C.2<\/sup>, Carvalho E.1<\/sup>, Carvalho D.1<\/sup>, Delgado J.L.2<\/sup>, Medina J.L.1<\/sup><\/div>\n
1<\/sup>Endocrinology Service, S. Joao Hospital, Faculty of Medicine, University of Porto, Portugal, 2<\/sup>Immunology Service, S. Joao Hospital, Faculty of Medicine, University of Porto, Portugal<\/div>\n
\n

Abstract<\/h2>\n

Background:<\/strong> Subclinical hypothyroidism (SCH) is defined as raised serum TSH levels with circulating thyroid hormones within the reference range. It is uncertain whether treatment of SCH with L-thyroxine improves cardiovascular (CV) risk factors.
Objective:<\/strong> To evaluate the therapeutic effect of L-thyroxine in lipid profile, CRP (C-reactive protein) and homocysteine levels in SCH caused by autoimmune thyroiditis (AIT).
Patients and methods:<\/strong> We recorded total cholesterol (TC), HDL and LDL-cholesterol, triglycerides (TG), apolipoprotein B (ApoB), ApoA1, lipoprotein (a) (Lp[a]), homocysteine, CRP, folic acid and vitamin B12 levels, before and 6 months after starting treatment with L-thyroxine in 120 patients (mean age 45.7 ± 12.2 yr, 80 females, mean BMI 28.35 ± 0.8 Kg\/m2) with SCH (mean TSH 6.429 ± 0.534 mIU\/liter) not previously treated for thyroid or vascular disease. Statistical analysis was performed with Students t-test.
Results:<\/strong> are expressed as means ± SD. A two-tailed p value < 0.05 was considered significant. Results -There were no significant differences between folic acid, vitamin B12, homocysteine, CRP, and TG levels before and after L-thyroxine treatment. TC and LDL levels significantly decreased (199.29 ± 20.39 mg\/dl vs 152.25 ± 19.12 mg\/dl, p< 0.01; 116.12 ± 34.23 mg\/dl vs 91.22 ±16.25 mg\/dl, p< 0.01, respectively). Apo B levels also significantly decreased with L-thyroxine treatment (128.32 ± 44.11mg\/dl vs 97.84 ± 29.31mg\/dl, p< 0.01). Lp(a) levels were significantly lower after L-thyroxine treatment (31.96mg\/dl ±19.11mg\/dl vs 21.42 ± 18.12mg\/dl, p< 0.01). HDL and Apo A1 levels increased significantly after L-thyroxine treatment (45.18 ± 15.29mg\/dl vs 58.47 ± 18.10mg\/dl, p< 0.01; 124.48 ± 43.26mg\/dl vs 136.52 ± 56.39mg\/dl, p< 0.01, respectively).
Conclusions:<\/strong> Autoimmune SCH treated with L-thyroxine leads to significant improvement in CV risk factors.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Neves C.1, Alves M.1, Pereira M.1, Ramalho R.2, Ramos J.P.2, Guimaraes C.2, Carvalho E.1, Carvalho D.1, Delgado J.L.2, Medina J.L.1 1Endocrinology Service, S. Joao Hospital, Faculty of Medicine, University of Porto, Portugal, 2Immunology Service, S. Joao Hospital, Faculty of Medicine, University of Porto, Portugal Abstract Background: Subclinical hypothyroidism (SCH) is defined as raised serum TSH Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45,2,9],"tags":[],"class_list":["post-1355","post","type-post","status-publish","format-standard","hentry","category-volume-7-issue-3","category-journal-articles","category-volume-7"],"_links":{"self":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1355","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/comments?post=1355"}],"version-history":[{"count":0,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1355\/revisions"}],"wp:attachment":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/media?parent=1355"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/categories?post=1355"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/tags?post=1355"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}