{"id":1352,"date":"2026-01-24T08:35:20","date_gmt":"2026-01-24T08:35:20","guid":{"rendered":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/tsh-and-thyroid-hormone-values-in-schoolchildren-living-in-an-area-with-long-standing-iodine-suffici\/"},"modified":"2026-01-24T08:35:20","modified_gmt":"2026-01-24T08:35:20","slug":"tsh-and-thyroid-hormone-values-in-schoolchildren-living-in-an-area-with-long-standing-iodine-suffici","status":"publish","type":"post","link":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/tsh-and-thyroid-hormone-values-in-schoolchildren-living-in-an-area-with-long-standing-iodine-suffici\/","title":{"rendered":"TSH AND THYROID HORMONE VALUES IN SCHOOLCHILDREN LIVING IN AN AREA WITH LONG-STANDING IODINE SUFFICIENCY: CORRELATION WITH GENDER, PUBERTY AND ADIPOSITY"},"content":{"rendered":"
Kaloumenou I.1<\/sup>, Duntas L.2<\/sup>, Mastorakos G.2<\/sup>, Alevizaki M.2<\/sup>, Mantzou E.2<\/sup>, Mengreli Ch.3<\/sup>, Chiotis D.1<\/sup>, Papassotiriou I.4<\/sup>, Chrousos G.P. 1<\/sup>, Dacou-Voutetakis C.1<\/sup><\/div>\n
1<\/sup>Endocrine Unit, First Department of Pediatrics, Athens University School of Medicine, 2<\/sup>Department of Endocrinology and Metabolism “Evgenidion” Hospital, Athens University School of Medicine, 3<\/sup>Institute of Child Health, “Agia Sofia” Childrens Hospital, 4<\/sup>Department of Clinical Biochemistry, “Agia Sofia” Childrens Hospital,Athens <\/div>\n
\n

Abstract<\/h2>\n

Aim:<\/strong> To assess thyroid function in children and adolescents from an iodine replete area with respect to age, pubertal stage and body size.
Methods:<\/strong> Thyrotropin (TSH), triiodothyronine (T3), total thyroxine (T4), free thyroxine (FT4) and the T4\/T3 ratio, were determined in 440 schoolchildren (200 boys and 240 girls) aged 5-18yrs living in the Athens area (an iodine replete region). Body Mass Index (BMI), BMI standard deviation score (BMI-SDS) and Body Surface Area (BSA) were calculated.
Results:<\/strong> In girls, there was a negative correlation between age and TSH (r=-0.143, p=0.031), T3 (r=-0.337, p=0.0001), and FT4 (r=-0.365, p=0.001) levels. In boys, there was a negative correlation only between T3 levels and age (r=-0.207, p=0.005). TSH, T4 and T3 values in girls and T3 values in boys were lower at puberty compared to prepubertal stage (p<0.0005). Pubertal girls had lower TSH values than pubertal boys (p><0.02). Taking the 97th percentile value as cut-off point for TSH, subclinical hypothyroidism was found in 4.8% of boys and 4.4% of girls. BMI-SDS correlated negatively with T4\/T3 ratio in boys and with FT4 in girls. Correlations between ΒSΑ and T3, T4, TSH and FT4 were statistically significant in girls.
Conclusions:<\/strong> We conclude that: a) the incidence of subclinical hypothyroidism in schoolchildren of an iodine replete area is approximately 5%, b) estrogens may have a suppressive effect on the pituitary-thyroid axis and c) while BMI is correlated negatively with T4\/T3 ratio in boys and with FT4 in girls it appears that there is no significant correlation between the former and TSH in either gender. <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Kaloumenou I.1, Duntas L.2, Mastorakos G.2, Alevizaki M.2, Mantzou E.2, Mengreli Ch.3, Chiotis D.1, Papassotiriou I.4, Chrousos G.P. 1, Dacou-Voutetakis C.1 1Endocrine Unit, First Department of Pediatrics, Athens University School of Medicine, 2Department of Endocrinology and Metabolism “Evgenidion” Hospital, Athens University School of Medicine, 3Institute of Child Health, “Agia Sofia” Childrens Hospital, 4Department of Clinical Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45,2,9],"tags":[],"class_list":["post-1352","post","type-post","status-publish","format-standard","hentry","category-volume-7-issue-3","category-journal-articles","category-volume-7"],"_links":{"self":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/comments?post=1352"}],"version-history":[{"count":0,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1352\/revisions"}],"wp:attachment":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/media?parent=1352"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/categories?post=1352"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/tags?post=1352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}