{"id":1335,"date":"2026-01-24T08:35:20","date_gmt":"2026-01-24T08:35:20","guid":{"rendered":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/response-to-glucocorticoid-therapy-in-patients-with-graves-ophthalmopathy\/"},"modified":"2026-01-24T08:35:20","modified_gmt":"2026-01-24T08:35:20","slug":"response-to-glucocorticoid-therapy-in-patients-with-graves-ophthalmopathy","status":"publish","type":"post","link":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/response-to-glucocorticoid-therapy-in-patients-with-graves-ophthalmopathy\/","title":{"rendered":"RESPONSE TO GLUCOCORTICOID THERAPY IN PATIENTS WITH GRAVES? OPHTHALMOPATHY"},"content":{"rendered":"<div class=\"article-authors\">Beleslin B., Zarkovic M., Ciric J., Stojkovic M., Savic S., Trbojevic B.<\/div>\n<div class=\"article-institutes\">Institute of endocrinology, Belgrade, Serbia <\/div>\n<div class=\"article-abstract\">\n<h2>Abstract<\/h2>\n<p><strong>Background:<\/strong> Clucocorticoids are treatment od choice for moderate to severe Graves\\ ophthalmopathy (GO).<br \/><strong>Objective:<\/strong> The aim of this study was to evaluate effects of gender, age, smoking, duration of eye disease, duration of hyperthyroidism, Cnical activity score (CAS) and TSH receptor antibody (TSH r At) levels on the response to glucocorticoids in patients with GO.<br \/>Methods: Study group consisted of 42 patients with severe GO treated with 2 doses of 500mg of methylprednisolon during 3 days followed by oral prednisone 40mg\/d tapered to 10mg\/d in 4 weeks. The treatment lasted for 6 months.<br \/><strong>Results:<\/strong> After 6 months, 29 of 42 patients (69,1%) had a treatment response. Eleven of 13 nonsmokers (85%) and 18 of 29 smokers (62%) responded to treatment. Patients with CAS 4 responded better (77%) compared with patients with CAS&lt;4 who had treatment response of 50%. Favorable response was in group with shorter interval between the onset of eye disease and the start of treatment (14&plusmn;14 months vs. 16&plusmn;13) as well as in group with higher TSHrAt levels (16&plusmn;16 vs. 6&plusmn;2). The responders were not different from non-responders with regard to age, gender and duration of hyperthyroidism. <br \/><strong>Conclusion:<\/strong> The response to glucocorticoid therapy dependent on smoking behavior, CAS, duration of eye disease and TSHrAb levels. <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Beleslin B., Zarkovic M., Ciric J., Stojkovic M., Savic S., Trbojevic B. Institute of endocrinology, Belgrade, Serbia Abstract Background: Clucocorticoids are treatment od choice for moderate to severe Graves\\ ophthalmopathy (GO).Objective: The aim of this study was to evaluate effects of gender, age, smoking, duration of eye disease, duration of hyperthyroidism, Cnical activity score (CAS) <a class=\"read-more\" href=\"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/response-to-glucocorticoid-therapy-in-patients-with-graves-ophthalmopathy\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45,2,9],"tags":[],"class_list":["post-1335","post","type-post","status-publish","format-standard","hentry","category-volume-7-issue-3","category-journal-articles","category-volume-7"],"_links":{"self":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/comments?post=1335"}],"version-history":[{"count":0,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1335\/revisions"}],"wp:attachment":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/media?parent=1335"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/categories?post=1335"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/tags?post=1335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}