{"id":1300,"date":"2026-01-24T08:35:20","date_gmt":"2026-01-24T08:35:20","guid":{"rendered":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/measurement-of-basal-serum-thyroglobulin-tg-with-ultrasensitive-assays-on-levo-thyroxine-therapy-lt4\/"},"modified":"2026-07-29T18:38:53","modified_gmt":"2026-07-29T18:38:53","slug":"measurement-of-basal-serum-thyroglobulin-tg-with-ultrasensitive-assays-on-levo-thyroxine-therapy-lt4","status":"publish","type":"post","link":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/measurement-of-basal-serum-thyroglobulin-tg-with-ultrasensitive-assays-on-levo-thyroxine-therapy-lt4\/","title":{"rendered":"MEASUREMENT OF BASAL SERUM THYROGLOBULIN (TG) WITH ULTRASENSITIVE ASSAYS ON LEVO-THYROXINE THERAPY (LT4) IN THE FOLLOW-UP OF PATIENTS WITH DIFFERENTIATED THYROID CARCINOMA (DTC): TOO EARLY TO DISMISS THE RHTSH STIMULATION TEST"},"content":{"rendered":"<div class=\"article-authors\">Castagna M. G., Cipri C., Tala H., Fioravanti C., Pasqui L., Sestini F., Brilli L. Belardini V., Ghezzi M., Pacini F.<\/div>\n<div class=\"article-institutes\">Department of Internal Medicine, Endocrinology, Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy<\/div>\n<div class=\"article-abstract\">\n<h2>Abstract<\/h2>\n<p>Recently, two different ultrasensitive serum Tg assays with low functional sensitivity (FS) (0.11 ng\/ml Tg Access and 0.02 ng\/ml Tg e-Iason) became commercially available. Aim of this retrospective study was to evaluate whether the use of these assays in the follow-up of DTC patients during suppressive LT4 therapy, might have the same or better diagnostic accuracy compared to the traditional Tg assay. <br \/><strong>Methods:<\/strong> We studied 215 DTC patients who underwent routine follow-up of DTC including rhTSH-Tg stimulation test (Tg Immulite, FS of 0.9 ng\/ml) and neck ultrasound. All patients had an undetectable basal Tg and negative TgAb. According to the results of the test 173\/215 (80%) met the criteria of complete remission and 42\/215 (20%) had some evidence of persistent disease. <br \/><strong>Results:<\/strong> Using ultrasensitive assays the diagnostic accuracy of basal Tg in detecting patients in complete remission or patients with persistent disease is reported in the table. <br \/><strong>Conclusions:<\/strong> Using basal Tg with a FS of 0.13 ng\/ml without performing rhTSH-Tg stimulation carried a 11.0% of false positive and 26.1% of false negative results. Using basal Tg with a FS of 0.04 ng\/ml there were 2.4% of false negative and 67.7% of false positive results. Based on these results we believe that the use of ultrasensitive assays will expose too many patients probably free of disease to an intensive follow-up and thus at this moment has not advantage over the traditional follow-up strategy based on the combination of rhTSH-Tg stimulation test and neck ultrasound.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Castagna M. G., Cipri C., Tala H., Fioravanti C., Pasqui L., Sestini F., Brilli L. Belardini V., Ghezzi M., Pacini F. Department of Internal Medicine, Endocrinology, Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy Abstract Recently, two different ultrasensitive serum Tg assays with low functional sensitivity (FS) (0.11 ng\/ml Tg Access <a class=\"read-more\" href=\"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/measurement-of-basal-serum-thyroglobulin-tg-with-ultrasensitive-assays-on-levo-thyroxine-therapy-lt4\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-1300","post","type-post","status-publish","format-standard","hentry","category-journal-articles"],"_links":{"self":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/comments?post=1300"}],"version-history":[{"count":1,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1300\/revisions"}],"predecessor-version":[{"id":11827,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1300\/revisions\/11827"}],"wp:attachment":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/media?parent=1300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/categories?post=1300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/tags?post=1300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}