{"id":1259,"date":"2026-01-24T08:35:20","date_gmt":"2026-01-24T08:35:20","guid":{"rendered":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/novel-insights-into-thyroid-gene-expression-in-non-mammalian-vertebrates-comparative-studies-using-x\/"},"modified":"2026-01-24T08:35:20","modified_gmt":"2026-01-24T08:35:20","slug":"novel-insights-into-thyroid-gene-expression-in-non-mammalian-vertebrates-comparative-studies-using-x","status":"publish","type":"post","link":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/novel-insights-into-thyroid-gene-expression-in-non-mammalian-vertebrates-comparative-studies-using-x\/","title":{"rendered":"NOVEL INSIGHTS INTO THYROID GENE EXPRESSION IN NON-MAMMALIAN VERTEBRATES &#8211; COMPARATIVE STUDIES USING XENOPUS LAEVIS AS A MODEL ORGANISM"},"content":{"rendered":"<div class=\"article-authors\">Opitz R., Lorenz C., Trubiroha A., Kloas W. <\/div>\n<div class=\"article-institutes\">Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany<\/div>\n<div class=\"article-abstract\">\n<h2>Abstract<\/h2>\n<p>function, molecular data on thyroid responses to TSH are still mainly limited to a few mammalian model species. To gain insights into molecular mechanisms of thyroid function in non-mammalian vertebrates, we used real-time PCR to analyze candidate gene expression profiles in thyroids of X. laevis tadpoles under different physiological conditions. First, thyroid goitrogenesis was induced by various compounds acting through different modes of action to identify transcripts regulated by TSH overstimulation. <br \/>Further, by exploiting the unique developmental profile of thyroid activity during normal metamorphosis, we assessed the physiological relevance of altered thyroid gene expression for the progression of thyroid hormone-dependent larval development. Finally, ex vivo organ culture of tadpole thyroids was used to elucidate regulatory mechanisms of gene expression. Expression profiling in these three experimental models provided evidence that TSH is a primary regulatory factor particularly for genes related to thyroid hormone synthesis and genes involved in protein synthesis, processing and intracellular traffic. Interestingly, expression patterns of genes involved in iodide metabolism (e.g., deiodinases), cell proliferation and negative growth regulation suggest that iodide auto-regulation and\/or other still poorly defined mechanisms contribute to the regulation of thyroid gene expression in the amphibian thyroid. Of particular interest was the differential regulation of some transcripts in vivo following inhibition of iodide uptake and iodide organification. <br \/>Results from ex vivo organ culture experiments confirmed the central role of the cAMP-protein kinase a pathway in mediating TSH effects for many but not all genes. The results observed in Xenopus tadpoles will be discussed from a comparative perspective.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Opitz R., Lorenz C., Trubiroha A., Kloas W. Department of Inland Fisheries, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany Abstract function, molecular data on thyroid responses to TSH are still mainly limited to a few mammalian model species. To gain insights into molecular mechanisms of thyroid function in non-mammalian vertebrates, we used real-time <a class=\"read-more\" href=\"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/2026\/01\/24\/novel-insights-into-thyroid-gene-expression-in-non-mammalian-vertebrates-comparative-studies-using-x\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45,2,9],"tags":[],"class_list":["post-1259","post","type-post","status-publish","format-standard","hentry","category-volume-7-issue-3","category-journal-articles","category-volume-7"],"_links":{"self":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/comments?post=1259"}],"version-history":[{"count":0,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/posts\/1259\/revisions"}],"wp:attachment":[{"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/media?parent=1259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/categories?post=1259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/peaceful-mccarthy.213-158-90-25.plesk.page\/index.php\/wp-json\/wp\/v2\/tags?post=1259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}